Foscarnet definition of foscarnet by the free dictionary. Foscarnet is superior to vidarabine in the treatment of acyclovirresistant hsv infections in patients with aids, and remains a treatment of choice for this illness at a dose of 40 mgkg three times daily 96. Jan 26, 2020 a type of abnormal heartbeat prolonged qt interval has happened with foscarnet. Antivirales universidad centroccidental lisandro alvarado. Jul 22, 2019 foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with a molecular formula of na 3 co 5 p6 h 2 o and a molecular weight of 300. Each milliliter of foscavir contains 24 mg of foscarnet. Activity of penciclovir in antiviral assays againts herpes simplex virus. Permiten al ser humano realizar determinados trabajos con mayor comodidad y menor esfuerzo. Foscarnet sodium has the potential to chelate divalent metal ions, such as calcium and magnesium, to form stable coordination compounds. Clinically, foscarnet is employed almost exclusively to treat infections with cytomegalovirus cmv particularly when ganciclovir cannot be used and acyclovirresistant herpes simplex virus hsv and varicella zoster virus vzv.
The chemical name of foscarnet sodium is phosphonoformic acid, trisodium salt. Foscavir has the potential to chelate divalent metal ions, such as calcium and magnesium, to form stable coordination compounds. Efficacy of intravitreal foscarnet in a patient with aids. Foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with a molecular formula of na 3 co 5 p6 h 2 o and a molecular weight of 300. Intravitreal administration to patients with cmv retinitis has been reported. Call your doctor right away if you have a fast or abnormal heartbeat, or if you pass out. Dec 11, 2012 foscarnet dosages must be adjusted according to renal function. It is classified as a pyrophosphate analog dna polymerase inhibitor. Foscavir injection is a sterile, isotonic aqueous solution for intravenous administration only. Topical treatment of recurrent genital herpes simplex virus infections with trisodium phosphonoformate foscarnet.
Composicion, indicaciones, presentacion y contraindicaciones. A type of abnormal heartbeat prolonged qt interval has happened with foscarnet. Low white blood cell counts have happened with foscarnet. Foscarnet is the conjugate base of a chemical compound with the formula ho 2 cpo 3 h 2. Foscarnet definition is a hydrated sodium salt na3co5p6h2o that is administered intravenously to individuals infected with hiv to treat retinitis caused by a cytomegalovirus. Pdf topical treatment of recurrent genital herpes simplex. Foscarnet fda prescribing information, side effects and uses. Foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with an empirical formula of na3co5p6 h20 and a molecular weight of 300. Foscarnet is a synthetic organic analog of inorganic pyrophosphate with activity against several types of viruses, but primarily used for the treatment of cytomegalovirus retinitis.
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